A University of Michigan-led study found that applying silver diamine fluoride can stop tooth decay in young children without the need for drilling or anesthesia.
Key facts
- •The clinical trial included 830 children younger than age 6.
- •Researchers found that 38% SDF stopped tooth decay in more than half of affected baby teeth when applied every six months.
- •The study was led by the University of Michigan in collaboration with researchers from New York University, the University of Iowa, and Indiana University.
- •The National Institute of Dental and Craniofacial Research provided more than $12 million to support the study.
- •SDF has been used off-label in the United States since 2014 for reducing tooth sensitivity.
A Phase III clinical trial has provided the data necessary to support FDA approval of silver diamine fluoride (SDF) as a treatment for tooth decay. The study, which involved 830 children under age 6, demonstrated that applying the liquid every six months can effectively stop decay in baby teeth. This non-invasive method offers an alternative to traditional fillings, which require drilling and often sedation for young patients.
By the numbers
Study Methodology and Findings
The research, published in JAMA Pediatrics, recruited participants from dental and medical practices, as well as Head Start programs in Michigan, New York, and Iowa. Researchers found that a 38% concentration of SDF successfully stopped decay in more than half of affected teeth when applied biannually. Unlike standard procedures that involve removing damaged tooth material, SDF is painted directly onto the cavity with a sponge-tipped applicator.
Clinical Implications and Limitations
While effective, the treatment causes the decayed portion of the tooth to turn permanently dark. Lead investigator Margherita Fontana noted that the treatment is safe for children as young as 1 and could be particularly beneficial for patients with dental anxiety, physical or developmental disabilities, or limited access to conventional care. The study was supported by over $12 million in funding from the National Institute of Dental and Craniofacial Research.
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This article was independently rewritten by ManyPress editorial AI from reporting originally published by ScienceDaily.
